Del Vecchio’s group focuses on model-based analysis, design, and control of biomolecular circuits in living cells. The objective of the research is to make genetic circuits more modular, robust to context, and hence make design more scalable. At the same time, we are investigating circuit design approaches that will enable accurate and precise in vivo control of gene expression. One of our target applications is the design of synthetic genetic circuits that accurately control cell fate-determining transcription factor levels, for reprogramming cell fate. Our approach is grounded on rigorous mathematical analysis of physics-based models of biological network dynamics, on the development of new control-theoretic tools for design, and on theory-educated experiments in living cells, from bacterial to mammalian.
C. McBride and D. Del Vecchio
ACS Synthetic Biology
C. McBride, T. Grunberg, and D. Del Vecchio
Current Opinion in Systems Biology
N. Shakiba, R. D. Jones, R. Weiss, and D. Del Vecchio