Del Vecchio’s group focuses on model-based analysis, design, and control of biomolecular networks in living cells. The objective is to make the engineering of synthetic genetic circuits in living organisms more robust to context, modular, and hence more scalable. One of our target applications is the design of synthetic genetic circuits that control cell fate to produce patient-specific somatic cells for regenerative medicine. Our approach is grounded on rigorous mathematical analysis of physics-based models of biological network dynamics, on control-theoretic tools for design, and on theory-educated experiments in living cells, from bacterial to mammalian.
Y. Qian, C. McBride, and D. Del Vecchio
Annual Reviews in Control, Robotics, and Autonomous Systems
M. Ali, E. D. Sontag, and D. Del Vecchio
R. Shah and D. Del Vecchio