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Journal Publications

Resource competition shapes CRISPR-mediated gene activation

K. Aravind-Manoj and D. Del Vecchio

Journal Publications Cell Systems December 2025

Stochastic modeling of epigenetic memory

S. Bruno and D. Del Vecchio

Journal Publications npc Systems Biology and Applications March 2026

Analog epigenetic memory revealed by targeted chromatin editing

S. Palacios, S. Bruno, E. Salibi, R. Weiss, I. Goodchild-Michelman, A. Kane, K. Ilia, and D. Del Vecchio

Journal Publications Cell Genomics Sept 2025

Epigenetic memory: The role of the crosstalk between DNA methylation and histone modifications

Domitilla Del Vecchio

Journal Publications Computational and Structural Biotechnology Journal September, 2025

Coclique Level Structure for Stochastic Chemical Reaction Networks

Simone Bruno, Yi Fu, Felipe A. Campos, Domitilla Del Vecchio, and Ruth J. Williams

Journal Publications Journal of Mathematical Biology July 2025

Machine learning for synthetic gene circuit engineering

S. Palacios, J. J. Collins, and D. Del Vecchio

Journal Publications Current Opinion in Biotechnology January 2025

Analysis of singularly perturbed stochastic chemical reaction networks motivated by applications to epigenetic cell memory

Simone Bruno, Felipe A. Campos, Yi Fu, Domitilla Del Vecchio, Ruth J. Williams

Journal Publications SIAM Journal on Applied Dynamical Systems May 2024

A Fieldable Process for Sensitive Detection of Airborne Viruses via Electrophoresis-based RNA Enrichment

H. Du, S. Bruno, K. Overholt, S. Palacios, H.-H. Huang, C. Barajas, B. Gross, C. Lee, H. K. Evile, N. Rufino de Sousa, A. G. Rothfuchs, and D. Del Vecchio

Journal Publications Biosensors and Bioelectronics: X May 2024

Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming

S. Bruno, T. Schlaeger, and D. Del Vecchio

Journal Publications npj Systems Biology and Applications November 2023

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts

Katherine Ilia, Nika Shakiba, Trevor Bingham, Ross D. Jones, Michael M. Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James J. Collins, Domitilla Del Vecchio*, Thorsten M. Schlaeger*

Journal Publications Science Advances October 2023

Identifiability of Chemical Reaction Networks with Intrinsic and Extrinsic Noise1 from Stationary Distributions

Ted Grunberg and Domitilla Del Vecchio

Journal Publications SIAM Journal on Applied Dynamical Systems April 2023

Comparison Theorems for Stochastic Chemical Reaction Networks

Felipe A. Campos*, Simone Bruno*, Yi Fu, Domitilla Del Vecchio, and Ruth J. Williams

Journal Publications Bulletin of Mathematical Biology Feb 2023

Incoherent merger network for robust ratiometric gene expression response

Ukjin Kwon, Hsin-Ho Huang, Jorge L. Chavez, Kathryn Beabout, Svetlana Harbaugh, and Domitilla Del Vecchio

Journal Publications Nucleic Acids Research Jan 2023

Mathematical analysis of the limiting behaviors of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Journal Publications Journal Mathematics of Control, Signals, and Systems Jan 2023

Feedforward growth rate control mitigates gene activation burden

C. Barajas, HH. Huang, J. Gibson, L. Sandoval, and D. Del Vecchio

Journal Publications Nature Communications October 2022

Mathematical analysis of the limiting behaviors of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Journal Publications Mathematics of Control, Signals, and Systems Sept 2022

Epigenetic cell memory: The gene’s inner chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Journal Publications PLOS Computational Biology February 2022

Squaring a circle: To what extent are traditional circuit analogies impeding synthetic biology?

K. Ilia and D. Del Vecchio

Journal Publications GEN Biotechnology February 2022

Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles

R.D. Jones, Y. Qian, K. Ilia, B. Wang, M.T. Laub, D. Del Vecchio*, R. Weiss*

Journal Publications Nature Communications February 2022

Synthetic biology by controller design

Carlos Barajas and Domitilla Del Vecchio

Journal Publications Current Opinion in Biotechnology February 2022

Predicting Composition of Genetic Circuits with Resource Competition: Demand and Sensitivity

C. McBride and D. Del Vecchio

Journal Publications ACS Synthetic Biology October 2021

Design of Genetic Circuits that are Robust to Resource Competition

C. McBride, T. Grunberg, and D. Del Vecchio

Journal Publications Current Opinion in Systems Biology July, 2021

Context-aware synthetic biology by controller design: engineering the mammalian cell

N. Shakiba, R. D. Jones, R. Weiss, and D. Del Vecchio

Journal Publications Cell Systems May 2021

dCas9 regulator to neutralize competition in CRISPRi circuits

H-H. Huang*, M. Bellato*, Y. QIan, P. Cardenas, L. Pasotti, P. Magni, and D. Del Vecchio

Journal Publications Nature Communications Jan. 2021

Robustness of networked systems to unintended interactions with application to engineered genetic circuits

Y. Qian and D. Del Vecchio

Journal Publications IEEE Trans. on Control of Network Systems January 2021

An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

R. D. Jones, Y. Qian, V. Siciliano, B. DiAndreth, J. Huh, R. Weiss, and D. Del Vecchio

Journal Publications Nature Communications August 2020

Effects of spatial heterogeneity on bacterial genetic circuits

C. Barajas and D. Del Vecchio

Journal Publications PLOS Comput. Biol. July 2020

Reprogramming multistable monotone systems with application to cell fate control

R. Shah and D. Del Vecchio

Journal Publications IEEE Transactions on Network Science and Engineering June 2020

Modular Analysis and Design of Biological Circuits

T. Grunberg and D. Del Vecchio

Journal Publications Current Opinion in Biotechnology November 2019

The Number of Equilibrium Points of Perturbed Nonlinear Positive Dynamical Systems

C. McBride and D. Del Vecchio

Journal Publications Automatica October 2019

The Effect of Loads in Molecular Communications

C. McBride, R. Shah, and D. Del Vecchio

Journal Publications Proc. of the IEEE April 2019

Multi-modality in gene regulatory networks with slow promoter kinetics

M. Ali Al-Radhawi, D. Del Vecchio, and E. D. Sontag

Journal Publications PLOS Comput. Biol. January 2019

A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

H-H. Huang*, Y. Qian*, and D. Del Vecchio

Journal Publications Nature Communications December 2018

A Singular Singular Perturbation Problem Arising from a Class of Biomolecular Feedback Controllers

Y. Qian and D. Del Vecchio

Journal Publications IEEE Control Systems Letters May 2018

Future Systems and Control Research in Synthetic Biology

D. Del Vecchio, Y. Qian, R. M. Murray, and E. D. Sontag

Journal Publications IFAC Annual Reviews in Control May 2018

Reduced Linear Noise Approximation for Biochemical Reaction Networks with Time-scale Separation : The stochastic tQSSA+

N. Herath and D. Del Vecchio

Journal Publications Journal of Chemical Physics February 2018

Deterministic-Like Model Reduction for a Class of Stochastic Differential Equations with Time-Scale Separation

N. Herath and D. Del Vecchio

Journal Publications IEEE Trans. on Aut. Control January 2018

Realizing "integral control" in living cells: How to overcome leaky integration due to dilution?

Y. Qian and D. Del Vecchio

Journal Publications Journal of Royal Soc. Interface January 2018

Programming cells to work for US

Y. Qian, C. McBride, and D. Del Vecchio

Journal Publications Annual Reviews in Control, Robotics, and Autonomous Systems August 2017

Signaling architectures that transmit unidirectional information despite retroactivity

R. Shah and D. Del Vecchio

Journal Publications Biophysical Journal June 2017

Resource Competition Shapes the Response of Genetic Circuits

Y. Qian, H-H. Huang, J. Jimenez, and D. Del Vecchio

Journal Publications ACS Synthetic Biology March 2017

Safety Verification and Control for Collision Avoidance at Road Intersections

H. Ahn and D. Del Vecchio

Journal Publications IEEE Trans. Automatic Control June 2017

A blueprint for a synthetic genetic feedback controller to reprogram cell fate

D. Del Vecchio, H. Abdallah, Y. Qian, and J. J. Collins

Journal Publications Cell Systems November 2016

Control Theory Meets Synthetic Biology

D. Del Vecchio, Y. Qian, and A. Dy

Journal Publications Journal of the Royal Society Interface June 2016.

Compositional Context Effects in Synthetic Gene Networks

E. Yeung, A. J. Dy, K. B. Martin, A. H. Ng, D. Del Vecchio, J. L. Beck6, J. J. Collins, and R. M. Murray

Journal Publications Cell Systems June 2017

Creating single-copy genetic circuits

Lee, J.W., Gyorgy, A., Cameron, D.E., Pyenson, N., Choi, K.R., Way, J.C., Silver, P.A., Del Vecchio, D., and Collins, J.J.

Journal Publications Molecular Cell June 2016.

Supervisory Control for Collision Avoidance in Vehicular Networks Using Discrete Event Abstractions

E. Dallal, A. Colombo, D. Del Vecchio, and S. Lafortune

Journal Publications Discrete Event Dynamic Systems April 2016.

Design of driver-assist systems under probabilistic safety specifications near stop signs

M. Forghani, J. McNew, D. Hoehener, and D. Del Vecchio,

Journal Publications IEEE Tsans. on Automation Science and Engineering, November 2015.

Isocost lines describe the cellular economy genetic circuits

A. Gyorgy, J. Jimenez, J. Yazbek, H.-H. Huang, H. Chung, R. Weiss and D. Del Vecchio,

Journal Publications Biophysical Journal, June 2015.

Estimation for decentralized safety control under communication delay and measurement uncertainty

D. Bresch-Pietri and D. Del Vecchio

Journal Publications Automatica, May 2015.

Modularity, context dependence, and insulation in engineered biological circuits (Draft)

D. Del Vecchio

Journal Publications Trends in Biotechnology (Cell Press) November 2014

A Load Driver Device for Engineering Modularity in Biological Networks

D. Mishra, P. M. Rivera-Ortiz, A. Lin, D. Del Vecchio(*), and R. Weiss(*) [(*)=co-corresponding authors ]

Journal Publications Nature Biotechnology September 2014.

New Device Could Make Large Biological Circuits Practical

Journal Publications MIT News November 2014.

Lightening the load in synthetic biology

News and Views

Journal Publications Nature Biotechnology November 2014.

A Synthetic Tunable Amplifying Buffer Circuit in E. coli

K. Nilgiriwala, J. Jimenez, P. M. Rivera, and D. Del Vecchio

Journal Publications ACS Synthetic Biology October 2014.

Least Restrictive Supervisors for Intersection Collision Avoidance: A Scheduling Approach

A. Colombo and D. Del Vecchio

Journal Publications IEEE Trans. Aut. Control November 2014.

Modular Composition of Gene Transcription Networks

A. Gyorgy and D. Del Vecchio,

Journal Publications PLOS Computational Biology, DOI: 10.1371/journal.pcbi.1003486 March 2014

A Control Theoretic Framework for Modular Analysis and Design of Biomolecular Networks

D. Del Vecchio

Journal Publications IFAC Reviews in Control, Vol 37(2):333-345 December 2013.

Control for Safety Specifications of Systems with Imperfect Information on a Partial Order (draft)

R. Ghaemi and D. Del Vecchio

Journal Publications IEEE Trans. Automatic Control 2013

Cooperative Collision Avoidance at Intersections: Algorithms and Experiments

M. Hafner, D. Cunningham, L. Caminiti, and D. Del Vecchio,

Journal Publications IEEE Trans. Intelligent Transportation Systems 2013

Retroactivity Controls the Temporal Dynamics of Gene Transcription

S. Jayanthi, K. Nilgiriwala, and D. Del Vecchio

Journal Publications ACS Synthetic Biology 2013

Modularity in Signaling Systems - Perspective Paper

D. Del Vecchio,

Journal Publications Physical Biology 2012

A Contraction Theory Approach to Singularly Perturbed Systems

D. Del Vecchio and J-J. Slotine

Journal Publications IEEE Trans. Aut. Control 2012

Tuning Genetic Clocks through DNA Binding Sites

S. Jayanthi and D. Del Vecchio,

Journal Publications PLoS ONE 2012

Computational Tools for the Safety Control of a Class of Piecewise Continuous Systems with Imperfect Information on a Partial Order

M. Hafner and D. Del Vecchio, SIAM J.

Journal Publications on Control and Optimization, 2011

Load-induced Modulation of Signal Transduction Networks

P. Jiang, A. C. Ventura, S. D. Merajver, E. D. Sontag, A. J. Ninfa, and D. Del Vecchio

Journal Publications Science Signaling, Vol. 4, Issue 194, p. ra67,(Read Editor's choice Enlightening the Load by L. Brya 2011

Semiautonomous Multivehicle Safety: A Hybrid Control Approach

R. Verma and D. Del Vecchio,

Journal Publications IEEE Robotics and Automation Magazine, Vol. 18, Issue 3, page(s) 44 - 54 2011

Long Signaling Cascades Tend to Attenuate Retroactivity

H. R. Ossareh, A. C. Ventura, S. D. Merajver, and D. Del Vecchio,

Journal Publications Biophysical Journal, vol. 100(7):1617-1626 2011

Safety Control of Hidden Mode Hybrid Systems

R. Verma and D. Del Vecchio

Journal Publications IEEE Trans. Aut. Control, 2011

Retroactivity Attenuation in Bio-molecular Systems Based on Timescale Separation

S. Jayanthi and D. Del Vecchio

Journal Publications IEEE Trans. Aut. Control, vol. 56(4), pages 748-761 2011

Signaling properties of a covalent modification cycle are altered by a downstream target.

A. C. Ventura, P. Jiang, L. Van Wassenhove, D. Del Vecchio, S. D. Merajver, and A. J. Ninfa,

Journal Publications Proc. Natl. Acad. Sci. USA, vol. 107(22), pages 10032-10037 2010

A Method for Determining the Robustness of Bio-molecular Oscillator Models.

R. Ghaemi, J. Sun, P. Iglesias, and D. Del Vecchio.

Journal Publications BMC Systems Biology, 3:95, 2009

Design and Characterization of a Three-terminal Transcriptional Device through Polymerase Per Second.

P. Varadarajan and D. Del Vecchio.

Journal Publications IEEE Transactions on Nanobioscience, 8(3):281-9 2009

Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity.

D. Del Vecchio and E. D. Sontag

Journal Publications Special Issue of the European Journal of Control, vol. 15 (3-4), 2009

Observer-based Control of Block-Triangular Discrete Time Hybrid Automata on a Partial Order

D. Del Vecchio

Journal Publications International Journal of Robust and Nonlinear Control--Special Issue, vol. 19(14), pages 1581-1602, 2009

Cascade Estimators for Systems on a Partial Order

D. Del Vecchio.

Journal Publications Systems & Control Letters, pages 842-850 2008

Modular Cell Biology: Retroactivity and Insulation

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

Journal Publications Nature/EMBO Molecular Systems Biology, 4:161 2008

Development of a Scaled Vehicle with Longitudinal Dynamics of a HMMWV for an ITS Testbed

R. Verma, D. Del Vecchio, and H. Fathy.

Journal Publications IEEE/ASME Transactions on Mechatronics, vol. 13(1), pp. 46-57 2008.

Discrete State Estimators for Systems on a Lattice

D. Del Vecchio, R. M. Murray, and E. Klavins

Journal Publications Automatica, vol. 42, pp. 271-285 2006.

Boundary Control for an Industrial Under-actuated Tubular Chemical Reactor

D. Del Vecchio and N. Petit.

Journal Publications Journal of Process Control, vol. 15, pp. 771-784 2005.

Decomposition of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona.

Journal Publications Automatica, vol. 39(12), pp. 2085-2098 2003.

Adaptive Learning Control for Feedback Linearizable Systems

D. Del Vecchio, R. Marino, and P. Tomei

Journal Publications European Journal of Control, vol. 9, Nb. 5 2003.

Adaptive Control of Feedback Linearizable Systems by Orthogonal Approximation Functions

D. Del Vecchio, R. Marino, and P. Tomei.

Journal Publications International Journal of Adaptive Control and Signal Processing, vol. 16, pp. 635-652 2002.

Books and Book Chapters

A Computational Approach for Cell Fate Reprogramming

H. Abdallah and D. Del Vecchio

Books and Book Chapters Methods in Molecular Biology, Springer Nature January 2018

The "Power Network" of Genetic Circuits (long version)

Y. Qian and D. Del Vecchio

Books and Book Chapters Workshop Emerging Applications of Control and Systems Theory (EACST) September 2017

Biomolecular Feedback Systems Princeton Publishing Press

D. Del Vecchio and R. M. Murray

Books and Book Chapters Textbook October 2014.

Synthetic Biology

D. Del Vecchio and R. M. Murray

Books and Book Chapters In Encyclopedia of Systems and Control, Baillieul, John, Samad, Tariq (Eds.), Springer March 2015 (Updated October 2019)

The Impact of Retroactivity on the Behavior of Bio- molecular Systems

D. Del Vecchio

Books and Book Chapters In Design and Analysis of Bio-molecular Circuits, H. Koeppl, D. Densmore, M. di Bernardo, G. Setti 2011

Synthetic Biology: A Systems Engineering Perspective

D. Del Vecchio and E. D. Sontag

Books and Book Chapters In Control Theory and Systems Biology, P. A. Iglesias and B. P. Ingalls (Eds), pages 101-124, The MI 2009.

Complexity management in the state estimation of multi-agent systems

D. Del Vecchio and R. M. Murray

Books and Book Chapters In Cooperative Control of Distributed Multi-Agent Systems, J. Shamma (Ed), pages 377-407, John Wiley 2008

Selected Publications in Conference Proceedings

Stochastic Analysis of Plasmids Competition in a Bacterial Switch

I. Ruolo, E. Lu and D. Del Vecchio

Selected Publications in Conference Proceedings American Control Conference May 2026

Learning Genetic Circuit Modules with Neural Networks

Jichi Wang, Eduardo D. Sontag, and Domitilla Del Vecchio

Selected Publications in Conference Proceedings American Control Conference May 2026

Guaranteed multistability in a microRNA-based genetic network by formal methods

Nicholas Nolan, Emma L. Peterman, Kate E. Galloway, Eduardo D. Sontag, and Domitilla Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control August 2025

A model of chaperone competition in bacterial gene regulatory networks

N. Nolan, MT Laub, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference March 2024

Guaranteeing System-level Properties in Genetic Circuits Subject to Context Effects

Inigo X. Incer, Ayush Pandey, Nicholas Nolan, Emma L. Peterman, Kate E. Galloway, Eduardo D. Sontag, and Domitilla Del Vecchio

Selected Publications in Conference Proceedings August 2024

Assessing Feasibility in Resource Limited Genetic Networks

Carlos Eduardo Celeste Junior, Theodore Wu Grunberg and Domitilla Del Vecchio

Selected Publications in Conference Proceedings August 2024

Competition for binding targets results in paradoxical effects for simultaneous activator and repressor action

M. Ali Al-Radhawi, Krishna Manoj, Dhruv Jatkar, Alon Duvall, Domitilla Del Vecchio, and Eduardo D. Sontag

Selected Publications in Conference Proceedings March 2024

Multi-variable control to mitigate loads in CRISPRa networks

Krishna Manoj, Theodore W. Grunberg and Domitilla Del Vecchio

Selected Publications in Conference Proceedings August 2024

Co-design of Resource Limited Genetic Modules

C. E. Celeste Junior, I. Di Loreto, T. W. Grunberg, M. D. Di Benedetto, A. Borri, and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conference on Decision and Control July 2023

Error Bound for Hill-Function Approximations in a Class of StochasticTranscriptional Network Models

D. Hirsch, T. Grunberg, and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conference on Decision and Control July 2023

Robust model invalidation for chemical reaction networks usinggeneralized moments

T. Grunberg and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conference on Decision and Control July 2023

Emergent interactions due to resource competition in CRISPR-mediated genetic activation circuits

K. Manoj and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC 2022

Population-Level Model of the Transient Dynamics of a Toggle Switch with Growth Feedback

D. Hirsh and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC 2022

Identifiability of linear noise approximation models of chemical reaction networks from stationary distributions

T. Grunberg and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC 2022

Analytical and computational study of the stochastic behavior of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC 2022

Design of a long-term memory genetic toggle switch inspired by chromatin modification circuits

U. Kwan and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC 2022

Model reduction and stochastic analysis of the histone modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Selected Publications in Conference Proceedings European Control Conference March 2022

The impact of retroactivity on information exchange in molecular communications

F. Ratti, M. Magarini, and D. D. Vecchio

Selected Publications in Conference Proceedings NANOCOM: The ACM International Conference on Nanoscale Computing and Communication 2020

The Enhanced Finite State Projection algorithm using conditional moment closure and time-scale separation

U. Kwan, M. Naghnaeian, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control July 2020

Trade-offs in Robustness to Perturbations of Bacterial Population Controllers

C. McBride and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference 2020

Time-scale separation based design of biomolecular feedback controllers

T. Grunberg and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CDC, Accepted 2019

Stochastic analysis of genetic feedback controllers to reprogram a pluripotency gene regulatory network

Simone Bruno, M. Ali Al-Radhawi, Eduardo D. Sontag, and Domitilla Del Vecchio

Selected Publications in Conference Proceedings Proc of American Control Conference January 2019

Genetic Circuit-Host Ribosome Transactions: Diffusion-Reaction Model

Carlos Barajas and Domitilla Del Vecchio

Selected Publications in Conference Proceedings Proc of American Control Conference January 2019

Approximation of the Chemical Master Equation using conditional moment closure and time-scale separation

Ukjin Kwon, Mohammad Naghnaeian and Domitilla Del Vecchio

Selected Publications in Conference Proceedings Proc of American Control Conference

Reprogramming cooperative monotone dynamical systems

R. Shah and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conf. on Decision and Control August 2018

A Model for Resource Competition in CRISPR-Mediated Gene Repression

P. Chen, Y. Qian, and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conf. on Decision and Control August 2018

A Singular Singular Perturbation Problem Arising from a Class of Biomolecular Feedback Controllers

Y. Qian and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conf. on Decision and Control August 2018

Stochastic multistationarity in a model of the hematopoietic stem cell differentiation network

M. Ali Al-Radhawi, N. S. Kumar, E. D. Sontag, and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conf. on Decision and Control August 2018

Resource Sensor Design for Quantifying Resource Competition in Genetic Circuits

C. McBride and D. Del Vecchio

Selected Publications in Conference Proceedings IEEE Conf. on Decision and Control August 2018

Multi-time-scale biomolecular ‘quasi-integral’ controllers for set-point regulation and trajectory tracking

Y. Qian, T. Grunberg, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conf. March 2018

Robust Moment Closure Method for the Chemical Master Equation

M. Naghnaeian and D. Del Vecchio

Selected Publications in Conference Proceedings CCTA 2017

Analyzing and Exploiting the Effects of Protease Sharing in Genetic Circuits

C. McBride and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IFAC World Congress March 2017

Model order reduction for Linear Noise Approximation using time-scale separation

N. Herath and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2016

Mitigation of ribosome competition through distributed sRNA feedback

Y. Qian and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control 2016

Controller design under safety specifications for a class of monotone hybrid automata

d. Hoehener and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2016

Lane Departure Assist: A Formal Approach

D. Hohener, G. Huang, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2016

Model reduction for a class of singularly perturbed stochastic differential equations : Fast variable approximation

N. Herath and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2016

Loading as a Design Parameter of Genetic Circuits

N. Kumar and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of American Control Conference 2016

A Dynamical Model for the Low Efficiency of Induced Pluripotent Stem Cell Reprogramming

H. Abdallah, Y. Qian, and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2016

An N-stage Cascade of Phosphorylation Cycles as an Insulation Device for Synthetic Biological Circuits

R. Shah and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of to European Control Conference, 2016

Semi-autonomous Intersection Collision Avoidance through Job-shop Scheduling

H. Ahn and D. Del Vecchio,

Selected Publications in Conference Proceedings ACM Proc. of Hybrid Systems: Computation and Control, 2016

How retroactivity impacts\ the robustness of genetic networks

S. Mou and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2015

A contraction approach to o\ utput tracking via high gain feedback

A. Hamadeh, E. D. Sontag and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2015

Experimental Testing of a Supervisor for\ Multi-vehicle collision Avoidance at Intersections

H. Ahn, A Rizzi, A. Colombo and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of IROS, 2015

Safety Control of a Class of Stochastic Order Preserving Systems with Application to Collision Avoidance near Stop Signs

M. Forghani, J. McNew, D. Hoehener, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2015

Stochastic Hybrid Models for Predicting the Behavior of Drivers Facing the Yellow-Light-Dilemma

D. Hoehener, P. A. Green, and D. Del Vecchio,

Selected Publications in Conference Proceedings Proc. of American Control Conference 2015

Model reduction for a class of singularly perturbed stochastic differential equations

N. Herath, A. Hamadeh, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2015

Effective interaction graphs arising from resource limitations in gene networks

Y. Qian and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2015

Mitigation of resource competition in synthetic genetic circuits through feedback regulation

A. Hamadeh and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control 2014

Limitations and Trade-offs in Gene Expression due to Competition for Shared Cellular Resources

A. Gyorgy and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control, 2014

Integral Action with Time Scale Separation: A Mechanism for Modularity in Biological Systems

P. M. Rivera and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control, 2014

Design of safety distributed control under bounded communication delay

D. Bresh-Pietri and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference, 2014

Supervisory control for intersection collision avoidance in the presence of uncontrolled vehicles

H. Ahn and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference, 2014

Tradeoffs between retroactivity and noise in connected transcriptional components

N. Herath and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference, 2014

Retroactivity Attenuation through Signal Transduction Cascades

P. M. Rivera and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. American Control Conference 2014

Supervisory Control for Collision Avoidance in Vehicular Networks with Imperfect Measurements

E. Dallal, A. Colombo, D. Del Vecchio, and S. Lafortune

Selected Publications in Conference Proceedings Proc. IEEE Conference on Decision and Control 2013

How slaves affect a master module in gene transcription networks

A. Gyorgy and D. Del Vecchio.

Selected Publications in Conference Proceedings . Proc. IEEE Conference on Decision and Control 2013

Robust multi-agent collision avoidance through scheduling

L. Bruni, A. Colombo, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conference on Decision and Control 2013

A Control Theory Approach to Engineering Biomolecular Networks

D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IFAC Symposium on Nonlinear Control Systems (NOLCOS) 2013

Optimal Design of Phosphorylation-Based Insulation Devices

P. M. Rivera and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. American Control Conference 2013

Supervisory Control for Collision Avoidance in Vehicular Networks Using Discrete Event Abstractions

E. Dallal, A. Colombo, D. Del Vecchio and S. Lafortune.

Selected Publications in Conference Proceedings Proc. American Control Conference, 2013.

Retroactivity to the Input and Thevenin's Theorem for Complex Gene Transcription Networks

A. Gyorgy and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control 2012

Stochastic Analysis of Retroactivity in Transcriptional Networks through Singular Perturbation

R. Ghaemi and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference 2012.

Efficient algorithms for collision avoidance at intersections

A. Colombo and D. Del Vecchio

Selected Publications in Conference Proceedings . Hybrid Systems: Computation and Control, 2012

Development and experimental validation of a semi-autonomous cooperative active safety system

R. Verma and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control 2011

Safety control of piece-wise continuous order preserving systems

R. Ghaemi and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control, 2011

Supervisory control of differentially flat systems based on abstraction

A. Colombo and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control, 2011

Retroactivity Attenuation in Signaling Cascades

H. R. Ossareh and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control 2011

A Contraction Theory Approach to Singularly Perturbed Systems with Application to Retroactivity Attenuation

D. Del Vecchio and J-J. Slotine

Selected Publications in Conference Proceedings Proc. IEEE Conf. on Decision and Control, 2011

Control of Hidden Mode Hybrid Systems: Algorithm Termination

R. Verma and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of International IEEE Conference on Intelligent Transportation Systems 2011

Automated Vehicle-to-Vehicle Collision Avoidance at Intersections

M. Hafner, D. Cunningham, L. Caminiti, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of World Congress on Intelligent Transport Systems 2011

Tuning an Activator-Repressor Clock Employing Retroactivity

S. Jayanthi, A. Rosenberg, and D. Del Vecchio

Selected Publications in Conference Proceedings Proc. American Control Conference, 2011.

Control of Hybrid Automata with Hidden Modes: Translation to a Perfect State Information Problem .

R. Verma and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2010

Formal Design of a Provably Safe Robotic Roundabout System.

J. Duperret, M. Hafner, and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE/RSJ International Conference on Intelligent Robots and Systems, 2010

The Impact of Retroactivity on the Input/Output Characteristic of a Signaling Component

A. C. Ventura, P. Jiang, L. Van Wassenhove, A. J. Ninfa, S. D. Merajver, and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of Dynamic Systems and Control Conference 2010

Design of an insulation device using phosphotransfer systems

S. Jayanthi and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE International Symposium on Circuits and Systems (ISCAS), 2010.

Computation of Safety Control for Uncertain Piecewise Continuous Systems on a Partial Order.

M. Hafner and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2009.

Continuous Control of Hybrid Automata with Imperfect Mode Information Assuming Separation between State Estimation and Control.

R. Verma and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2009.

On the Compromise between Retroactivity Attenuation and Noise Amplification in Gene Regulatory Networks.

S. Jayanthi and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control 2009

Design of Insulating Devices for In Vitro Synthetic Circuits.

E. Franco, D. Del Vecchio and R. M. Murray.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2009.

Partial Order Techniques for Vehicle Collision Avoidance: Application to an Autonomous Roundabout Test-bed.

V. Desaraju, H. C. Ro, M. Yang, E. Tay, S. Roth, D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of International Conference on Robotics and Automation (ICRA) 2009.

A Separation Principle for a Class of Hybrid Automata on a Partial Order.

D. Del Vecchio, M. Malisoff, and R. Verma

Selected Publications in Conference Proceedings Proc. of American Control Conference 2009.

Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity.

D. Del Vecchio and E. D. Sontag.

Selected Publications in Conference Proceedings Proc. of European Control Conference (ECC), 2009

Retroactivity Attenuation in Transcriptional Networks: Design and Analysis of an Insulation Device

D. Del Vecchio and S. Jayanthi.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control December 2008, Cancun

Longitudinal Vehicle Dynamics Scaling and Implementation on a HIL Setup

R. Verma, D. Del Vecchio, and H. Fathy.

Selected Publications in Conference Proceedings Proc. of the Dynamic Systems and Control Conference, October 2008, Ann Arbor.

A Systems Theory with Retroactivity: Application to Transcriptional Modules

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

Selected Publications in Conference Proceedings Proc. of American Control Conference, June 2008, Seattle.

A Partial Order Approach for Low Complexity Control of Block Triangular Hybrid Automata

D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, December 2007, New Orleans.

Observer-based Control for Block-triangular Hybrid Automata.

D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control December 2007, New Orleans

Evaluating the Robustness of a Biochemical Network Model

R. Ghaemi and D. Del Vecchio.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control December 2007, New Orleans.

Design and Analysis of an Activator-Repressor Clock in E. coli

D. Del Vecchio

Selected Publications in Conference Proceedings Proc. of American Control Conference July 2007, New York.

Dynamics and Control of Synthetic Bio-molecular Networks

D. Del Vecchio and E.D. Sontag

Selected Publications in Conference Proceedings Proc. of American Control Conference, July 2007, New York.

A Partial Order Approach to Discrete Dynamic Feedback in a Class of Hybrid Systems

D. Del Vecchio

Selected Publications in Conference Proceedings Hybrid Systems: Computation and Control, April 2007, Pisa.

Discrete Dynamic Feedback for a Class of Hybrid Systems on a Lattice

D. Del Vecchio

Selected Publications in Conference Proceedings IEEE CCA/CACSD/ISIC 2006, Munich.

Cascade Discrete-Continuous State Estimators for a Class of Monotone Systems

D. Del Vecchio and R.M. Murray.

Selected Publications in Conference Proceedings Proc. of IFAC 2005, Praha.

Existence of Cascade Discrete-Continuous State Estimators for Systems on a Partial Order

D. Del Vecchio and R.M. Murray.

Selected Publications in Conference Proceedings Hybrid Systems: Computation a nd Control, 2005 Zurich, Switzerland.

Repressilators and Promotilators: Loop Dynamics in Gene Regulatory Networks

H. El Samad, D. Del Vecchio, and M. Khammash.

Selected Publications in Conference Proceedings Proc. of American Control Conference, 2005

Existence of Discrete State Estimators for Hybrid Systems on a Lattice

D. Del Vecchio and R.M. Murray.

Selected Publications in Conference Proceedings Proc. of IEEE Conference on Decision and Control, 2004 Atlantis, Bahamas.

Identification of Decision Rules in a Human Controlled System: Vehicles at a Traffic Intersection

C. L. Walton, D. Del Vecchio, and R. M. Murray.

Selected Publications in Conference Proceedings Proc. of International Conference of Robotics and Automation 2004, New Orleans.

Vision as a Compensatory Mechanism for Disturbance Rejection in Upwind Flight

M. B. Reiser, J. S. Humbert, M. J. Dunlop, D. Del Vecchio, R. M. Murray, M. H. Dickinson.

Selected Publications in Conference Proceedings Proc. of American Control Conference(Winner of best student paper competition) 2004, Boston.

Discrete State Estimators for a Class of Hybrid Systems on a Lattice

D. Del Vecchio and R. M. Murray.

Selected Publications in Conference Proceedings Hybrid Systems: Computation and Control 2004 Philadelphia, Pennsylvania.

Observation of Guarded Command Programs

D. Del Vecchio and E. Klavins.

Selected Publications in Conference Proceedings Proc of IEEE Conference on Decision and Control, 2003 Maui, Hawaii.

Classification of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona.

Selected Publications in Conference Proceedings Proc. of European Control Conference 2003 Cambridge (UK).

Segmentation of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona

Selected Publications in Conference Proceedings Proc of. American Control Conference 2003 Denver, Colorado.

Primitives for Human Motion: A Dynamical Approach

D. Del Vecchio, R. M. Murray, and P. Perona

Selected Publications in Conference Proceedings Proc. of IFAC 2002 Barcelona, Spain.

An Adaptive Learning Control for Feedback Linearizable Systems.

D. Del Vecchio, R. Marino, and P. Tomei.

Selected Publications in Conference Proceedings Proc. of American Control Conference, Washington, VA 2001.

Adaptive Learning Control for Robot Manipulators.

D. Del Vecchio, R. Marino, and P. Tomei

Selected Publications in Conference Proceedings Proc. of American Control Conference Washington, VA 2001.

Patents

Computationally efficient intersection collision avoidance system

MR Hafner, D Cunningham, L Caminiti, D Del Vecchio

Patents US Patent 8,965,676 2015

Computationally Efficient Intersection Collision Avoidance (ICA) System with Guaranteed Safety Performance

L. Caminiti, E. Quisenberry, C. Peplin, D. Del Vecchio, and R. Verma.

Patents U.S. Patent 8639437, 2014

Selected Abstracts

Multi-modality in gene regulatory networks with slow promoter kinetics

M. Ali, E. D. Sontag, and D. Del Vecchio

Selected Abstracts q-Bio Conference August 2017

Understanding and Mitigating the Effects of Limited Transcriptional Resources in Mammalian Cells

Ross Jones, Y. Qian, Ron Weiss, and Domitilla Del Vecchio

Selected Abstracts SEED Conference July 2017

Characterizing the effect of shared transcriptional resource in mammalian cells

Ross Jones, Y. Qian, Velia Siciliano, Domitilla Del Vecchio, and Ron Weiss

Selected Abstracts Mammalian Synthetic Biology Workshop 3.0 May 2016

A semi-autonomous algorithm for multi-vehicle collision avoidance at intersections with multi-conflict points

H. Ahn and D. Del Vecchio

Selected Abstracts . IROS Conference 2015

The role of ribosome autocatalysis and negative feedback in resource competition

F. Chandra and D. Del Vecchio.

Selected Abstracts FOSBE Boston 2015

Resource Limitations Lead to Hidden Interactions in Gene Networks

Y. Qian, H-H. Huang, and D. Del Vecchio.

Selected Abstracts SEED Conference Boston, 2015

Isocost lines determine the economy of shared cellular resources.

A. Gyorgy, J. Jimenez, D. Del Vecchio

Selected Abstracts SEED Conference Manhattan Beach, CA, 2014

Combating context-dependence in biological circuits with a load driver.

D. Mishra, P. M. Rivera-Ortiz, D. Del Vecchio, and R. Weiss

Selected Abstracts International Conference on Systems Biology, Denmark, 2013

Modular Composition of Gene Transcription Networks.

A. Gyorgy and D. Del Vecchio

Selected Abstracts International Conference on Systems Biology Denmark, 2013.

Modularity in Complex Gene Transcrition Networks.

A. Gyorgy and D. Del Vecchio

Selected Abstracts International Conference on Systems Biology, Toronto, 2012.

Insulation Mechanisms of in vivo Biomolecular Circuits.

K. Nilgiriwala, P. M. Rivera, and D. Del Vecchio.

Selected Abstracts International Conference on Systems Biology Toronto, 2012.

Impact of Retroactivity on Transcriptional Components.

S. Jayanthi and D. Del Vecchio

Selected Abstracts The 5th Annual q-bio Conference on Cellular Information Processing, Santa Fe, 2012.

Engineering Insulation from Retroactivity of the Frequency Response of Covalent Modification Cycles.

D. Del Vecchio

Selected Abstracts IEEE Biomedical Circuits & Systems Conference, San Diego, 2011.

Enforcing Safety of Cyber-Physical Systems Using Flatness and Abstraction.

A. Colombo and D. Del Vecchio.

Selected Abstracts IEEE/ACM Second International Conference on Cyber-Physical Systems Chicago, 2011.

A Control Theory Approach to Engineering Biomolecular Circuits.

D. Del Vecchio

Selected Abstracts 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Boston, 2011.

The Impact of Retroactivity on the Signal Processing of Transduction Networks.

P. Jiang, A. C. Ventura, S. Merajver, E. D. Sontag, A. J. Ninfa, and D. Del Vecchio.

Selected Abstracts The 5th Annual q-bio Conference on Cellular Information Processing, Santa Fe, 2011

Retroactivity changes the input/output steady-state characteristic of a transcriptional component.

S. Jayanthi and D. Del Vecchio

Selected Abstracts SB5.0: The 5th International Meeting on Synthetic Biology Stanford, 2011

A Dynamics Perspective on Modularity in Biomolecular Networks.

P. Jiang, A. C. Ventura, S. D. Merajver, A. J. Ninfa, and D. Del Vecchio.

Selected Abstracts International Conference on Systems Biology, Edinburgh, 2010.

Long Signaling Cascades Attenuate Retroactivity.

H. R. Ossareh, A. C. Ventura, S. D. Merajver, and D. Del Vecchio.

Selected Abstracts International Conference on Systems Biology Edinburgh, 2010

Control of Hybrid Automata with Imperfect Mode Information

D. Del Vecchio

Selected Abstracts Second Workshop on Numerical Software Verification San Francisco 2009

From Retroactivity to Insulation: a Novel Engineering Principle Learned from Natural Bio-molecular Systems

D. Del Vecchio,

Selected Abstracts Institute for Biological Engineering Conference San Francisco 2009

Tutorial Session: Partial order techniques for the analysis and synthesis of hybrid and embedded systems

Organizer: D. Del Vecchio Contributors: Jean-François Raskin (Computer Science Dept., Université Libre de Bruxelles), Georgios E. Fainekos and G Pappas (GRASP Lab, Upenn), Edward A. Lee (EECS, UC Berkeley), Derek Caveney and Lorenzo Caminiti (Toyota Tech

Selected Abstracts Proc. of Conference on Decision and Control, New Orleans 2007.

Modules and Retroactivity: Theoretical Framework, Analysis, and Design.

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

Selected Abstracts International Conference on Systems Biology Long Beach, 2007.

An Introduction to Control of Synthetic Bio-molecular Systems

D. Del Vecchio

Selected Abstracts Proc. of Conference on Decision and Control New Orleans 2007.

Workshops

Systems and Control Theory for Synthetic Biology

D. Del Vecchio

Workshops NSF- funded Workshop 2021

The compositionality problem in synthetic biology: New directions for control theory

D. Del Vecchio, R. M. Murray, and E. D. Sontag

Workshops MIT June 2017

Analysis and Design of Cyber-Physical Transportation Systems: Challenges, Progress, and Future Directions

Organizer: D. Del Vecchio

Workshops American Control Conference 2012