Publications

Journal Publications

Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming

S. Bruno, T. Schlaeger, and D. Del Vecchio

npj Systems Biology and Applications

Conditionally Accepted

November 2023

Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts

Katherine Ilia, Nika Shakiba, Trevor Bingham, Ross D. Jones, Michael M. Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James J. Collins, Domitilla Del Vecchio*, Thorsten M. Schlaeger*

Science Advances

Accepted

October 2023

Identifiability of Chemical Reaction Networks with Intrinsic and Extrinsic Noise1 from Stationary Distributions

Ted Grunberg and Domitilla Del Vecchio

SIAM Journal on Applied Dynamical Systems

Accepted

April 2023

Comparison Theorems for Stochastic Chemical Reaction Networks

Felipe A. Campos*, Simone Bruno*, Yi Fu, Domitilla Del Vecchio, and Ruth J. Williams

Bulletin of Mathematical Biology

Accepted

Feb 2023

Incoherent merger network for robust ratiometric gene expression response

Ukjin Kwon, Hsin-Ho Huang, Jorge L. Chavez, Kathryn Beabout, Svetlana Harbaugh, and Domitilla Del Vecchio

Nucleic Acids Research

Accepted

Jan 2023

Mathematical analysis of the limiting behaviors of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Journal Mathematics of Control, Signals, and Systems

Accepted

Jan 2023

Feedforward growth rate control mitigates gene activation burden

C. Barajas, HH. Huang, J. Gibson, L. Sandoval, and D. Del Vecchio

Nature Communications

Conditionally Accepted

October 2022

Mathematical analysis of the limiting behaviors of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

Mathematics of Control, Signals, and Systems

Accepted

Sept 2022

Epigenetic cell memory: The gene’s inner chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

PLOS Computational Biology

Accepted

February 2022

Squaring a circle: To what extent are traditional circuit analogies impeding synthetic biology?

K. Ilia and D. Del Vecchio

GEN Biotechnology

Accepted

February 2022

Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles

R.D. Jones, Y. Qian, K. Ilia, B. Wang, M.T. Laub, D. Del Vecchio*, R. Weiss*

Nature Communications

Accepted

February 2022

Synthetic biology by controller design

Carlos Barajas and Domitilla Del Vecchio

Current Opinion in Biotechnology

Conditionally Accepted

February 2022

Predicting Composition of Genetic Circuits with Resource Competition: Demand and Sensitivity

C. McBride and D. Del Vecchio

ACS Synthetic Biology

Conditionally Accepted

October 2021

Design of Genetic Circuits that are Robust to Resource Competition

C. McBride, T. Grunberg, and D. Del Vecchio

Current Opinion in Systems Biology

To Appear

July, 2021

Context-aware synthetic biology by controller design: engineering the mammalian cell

N. Shakiba, R. D. Jones, R. Weiss, and D. Del Vecchio

Cell Systems

Accepted

May 2021

dCas9 regulator to neutralize competition in CRISPRi circuits

H-H. Huang*, M. Bellato*, Y. QIan, P. Cardenas, L. Pasotti, P. Magni, and D. Del Vecchio

Nature Communications

Accepted

Jan. 2021

Robustness of networked systems to unintended interactions with application to engineered genetic circuits

Y. Qian and D. Del Vecchio

IEEE Trans. on Control of Network Systems

Conditionally Acceted

January 2021

An endoribonuclease-based feedforward controller for decoupling resource-limited genetic modules in mammalian cells

R. D. Jones, Y. Qian, V. Siciliano, B. DiAndreth, J. Huh, R. Weiss, and D. Del Vecchio

Nature Communications

Accepted

August 2020

Effects of spatial heterogeneity on bacterial genetic circuits

C. Barajas and D. Del Vecchio

PLOS Comput. Biol.

Accepted

July 2020

Reprogramming multistable monotone systems with application to cell fate control

R. Shah and D. Del Vecchio

IEEE Transactions on Network Science and Engineering

Accepted

June 2020

Modular Analysis and Design of Biological Circuits

T. Grunberg and D. Del Vecchio

Current Opinion in Biotechnology

Accepted

November 2019

The Number of Equilibrium Points of Perturbed Nonlinear Positive Dynamical Systems

C. McBride and D. Del Vecchio

Automatica

Accepted

October 2019

The Effect of Loads in Molecular Communications

C. McBride, R. Shah, and D. Del Vecchio

Proc. of the IEEE

Accepted

April 2019

Multi-modality in gene regulatory networks with slow promoter kinetics

M. Ali Al-Radhawi, D. Del Vecchio, and E. D. Sontag

PLOS Comput. Biol.

Accepted

January 2019

A quasi-integral controller for adaptation of genetic modules to variable ribosome demand

H-H. Huang*, Y. Qian*, and D. Del Vecchio

Nature Communications

Accepted

December 2018

A Singular Singular Perturbation Problem Arising from a Class of Biomolecular Feedback Controllers

Y. Qian and D. Del Vecchio

IEEE Control Systems Letters

Accepted

May 2018

Future Systems and Control Research in Synthetic Biology

D. Del Vecchio, Y. Qian, R. M. Murray, and E. D. Sontag

IFAC Annual Reviews in Control

To Appear

May 2018

Reduced Linear Noise Approximation for Biochemical Reaction Networks with Time-scale Separation : The stochastic tQSSA+

N. Herath and D. Del Vecchio

Journal of Chemical Physics

Accepted

February 2018

Deterministic-Like Model Reduction for a Class of Stochastic Differential Equations with Time-Scale Separation

N. Herath and D. Del Vecchio

IEEE Trans. on Aut. Control

Conditionally accepted

January 2018

Realizing "integral control" in living cells: How to overcome leaky integration due to dilution?

Y. Qian and D. Del Vecchio

Journal of Royal Soc. Interface

Accepted

January 2018

Programming cells to work for US

Y. Qian, C. McBride, and D. Del Vecchio

Annual Reviews in Control, Robotics, and Autonomous Systems

Accepted

August 2017

Signaling architectures that transmit unidirectional information despite retroactivity

R. Shah and D. Del Vecchio

Biophysical Journal

Accepted

June 2017

Resource Competition Shapes the Response of Genetic Circuits

Y. Qian, H-H. Huang, J. Jimenez, and D. Del Vecchio

ACS Synthetic Biology

Accepted

March 2017

Safety Verification and Control for Collision Avoidance at Road Intersections

H. Ahn and D. Del Vecchio

IEEE Trans. Automatic Control

Accepted

June 2017

A blueprint for a synthetic genetic feedback controller to reprogram cell fate

D. Del Vecchio, H. Abdallah, Y. Qian, and J. J. Collins

Cell Systems

Accepted

November 2016

Control Theory Meets Synthetic Biology

D. Del Vecchio, Y. Qian, and A. Dy

Journal of the Royal Society Interface

Accepted

June 2016.

Compositional Context Effects in Synthetic Gene Networks

E. Yeung, A. J. Dy, K. B. Martin, A. H. Ng, D. Del Vecchio, J. L. Beck6, J. J. Collins, and R. M. Murray

Cell Systems

Accepted

June 2017

Creating single-copy genetic circuits

Lee, J.W., Gyorgy, A., Cameron, D.E., Pyenson, N., Choi, K.R., Way, J.C., Silver, P.A., Del Vecchio, D., and Collins, J.J.

Molecular Cell

Accepted

June 2016.

Supervisory Control for Collision Avoidance in Vehicular Networks Using Discrete Event Abstractions

E. Dallal, A. Colombo, D. Del Vecchio, and S. Lafortune

Discrete Event Dynamic Systems

Accepted

April 2016.

Design of driver-assist systems under probabilistic safety specifications near stop signs

M. Forghani, J. McNew, D. Hoehener, and D. Del Vecchio,

IEEE Tsans. on Automation Science and Engineering,

Accepted

November 2015.

Isocost lines describe the cellular economy genetic circuits

A. Gyorgy, J. Jimenez, J. Yazbek, H.-H. Huang, H. Chung, R. Weiss and D. Del Vecchio,

Biophysical Journal,

Accepted

June 2015.

Estimation for decentralized safety control under communication delay and measurement uncertainty

D. Bresch-Pietri and D. Del Vecchio

Automatica,

Accepted

May 2015.

Modularity, context dependence, and insulation in engineered biological circuits (Draft)

D. Del Vecchio

Trends in Biotechnology (Cell Press)

Accepted

November 2014

A Load Driver Device for Engineering Modularity in Biological Networks

D. Mishra, P. M. Rivera-Ortiz, A. Lin, D. Del Vecchio(*), and R. Weiss(*) [(*)=co-corresponding authors ]

Nature Biotechnology

Accepted

September 2014.

New Device Could Make Large Biological Circuits Practical

MIT News

November 2014.

Lightening the load in synthetic biology

News and Views

Nature Biotechnology

November 2014.

A Synthetic Tunable Amplifying Buffer Circuit in E. coli

K. Nilgiriwala, J. Jimenez, P. M. Rivera, and D. Del Vecchio

ACS Synthetic Biology

Accepted

October 2014.

Least Restrictive Supervisors for Intersection Collision Avoidance: A Scheduling Approach

A. Colombo and D. Del Vecchio

IEEE Trans. Aut. Control

Accepted

November 2014.

Modular Composition of Gene Transcription Networks

A. Gyorgy and D. Del Vecchio,

PLOS Computational Biology, DOI: 10.1371/journal.pcbi.1003486

March 2014

A Control Theoretic Framework for Modular Analysis and Design of Biomolecular Networks

D. Del Vecchio

IFAC Reviews in Control, Vol 37(2):333-345

December 2013.

Control for Safety Specifications of Systems with Imperfect Information on a Partial Order (draft)

R. Ghaemi and D. Del Vecchio

IEEE Trans. Automatic Control

Accepted

2013

Cooperative Collision Avoidance at Intersections: Algorithms and Experiments

M. Hafner, D. Cunningham, L. Caminiti, and D. Del Vecchio,

IEEE Trans. Intelligent Transportation Systems

Accepted

2013

Retroactivity Controls the Temporal Dynamics of Gene Transcription

S. Jayanthi, K. Nilgiriwala, and D. Del Vecchio

ACS Synthetic Biology

Accepted

2013

Modularity in Signaling Systems - Perspective Paper

D. Del Vecchio,

Physical Biology

Accepted

2012

A Contraction Theory Approach to Singularly Perturbed Systems

D. Del Vecchio and J-J. Slotine

IEEE Trans. Aut. Control

Accepted

2012

Tuning Genetic Clocks through DNA Binding Sites

S. Jayanthi and D. Del Vecchio,

PLoS ONE

Accepted

2012

Computational Tools for the Safety Control of a Class of Piecewise Continuous Systems with Imperfect Information on a Partial Order

M. Hafner and D. Del Vecchio, SIAM J.

on Control and Optimization,

Accepted

2011

Load-induced Modulation of Signal Transduction Networks

P. Jiang, A. C. Ventura, S. D. Merajver, E. D. Sontag, A. J. Ninfa, and D. Del Vecchio

Science Signaling, Vol. 4, Issue 194, p. ra67,(Read Editor's choice Enlightening the Load by L. Brya

2011

Semiautonomous Multivehicle Safety: A Hybrid Control Approach

R. Verma and D. Del Vecchio,

IEEE Robotics and Automation Magazine, Vol. 18, Issue 3, page(s) 44 - 54

2011

Long Signaling Cascades Tend to Attenuate Retroactivity

H. R. Ossareh, A. C. Ventura, S. D. Merajver, and D. Del Vecchio,

Biophysical Journal, vol. 100(7):1617-1626

2011

Safety Control of Hidden Mode Hybrid Systems

R. Verma and D. Del Vecchio

IEEE Trans. Aut. Control,

Accepted

2011

Retroactivity Attenuation in Bio-molecular Systems Based on Timescale Separation

S. Jayanthi and D. Del Vecchio

IEEE Trans. Aut. Control, vol. 56(4), pages 748-761

2011

Signaling properties of a covalent modification cycle are altered by a downstream target.

A. C. Ventura, P. Jiang, L. Van Wassenhove, D. Del Vecchio, S. D. Merajver, and A. J. Ninfa,

Proc. Natl. Acad. Sci. USA, vol. 107(22), pages 10032-10037

2010

A Method for Determining the Robustness of Bio-molecular Oscillator Models.

R. Ghaemi, J. Sun, P. Iglesias, and D. Del Vecchio.

BMC Systems Biology, 3:95,

2009

Design and Characterization of a Three-terminal Transcriptional Device through Polymerase Per Second.

P. Varadarajan and D. Del Vecchio.

IEEE Transactions on Nanobioscience, 8(3):281-9

2009

Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity.

D. Del Vecchio and E. D. Sontag

Special Issue of the European Journal of Control, vol. 15 (3-4),

2009

Observer-based Control of Block-Triangular Discrete Time Hybrid Automata on a Partial Order

D. Del Vecchio

International Journal of Robust and Nonlinear Control--Special Issue, vol. 19(14), pages 1581-1602,

2009

Cascade Estimators for Systems on a Partial Order

D. Del Vecchio.

Systems & Control Letters, pages 842-850

2008

Modular Cell Biology: Retroactivity and Insulation

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

Nature/EMBO Molecular Systems Biology, 4:161

2008

Development of a Scaled Vehicle with Longitudinal Dynamics of a HMMWV for an ITS Testbed

R. Verma, D. Del Vecchio, and H. Fathy.

IEEE/ASME Transactions on Mechatronics, vol. 13(1), pp. 46-57

2008.

Discrete State Estimators for Systems on a Lattice

D. Del Vecchio, R. M. Murray, and E. Klavins

Automatica, vol. 42, pp. 271-285

2006.

Boundary Control for an Industrial Under-actuated Tubular Chemical Reactor

D. Del Vecchio and N. Petit.

Journal of Process Control, vol. 15, pp. 771-784

2005.

Decomposition of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona.

Automatica, vol. 39(12), pp. 2085-2098

2003.

Adaptive Learning Control for Feedback Linearizable Systems

D. Del Vecchio, R. Marino, and P. Tomei

European Journal of Control, vol. 9, Nb. 5

2003.

Adaptive Control of Feedback Linearizable Systems by Orthogonal Approximation Functions

D. Del Vecchio, R. Marino, and P. Tomei.

International Journal of Adaptive Control and Signal Processing, vol. 16, pp. 635-652

2002.

Selected Publications in Conference Proceedings

Co-design of Resource Limited Genetic Modules

C. E. Celeste Junior, I. Di Loreto, T. W. Grunberg, M. D. Di Benedetto, A. Borri, and D. Del Vecchio

IEEE Conference on Decision and Control

Accepted

July 2023

Error Bound for Hill-Function Approximations in a Class of StochasticTranscriptional Network Models

D. Hirsch, T. Grunberg, and D. Del Vecchio

IEEE Conference on Decision and Control

Accepted

July 2023

Robust model invalidation for chemical reaction networks usinggeneralized moments

T. Grunberg and D. Del Vecchio

IEEE Conference on Decision and Control

Accepted

July 2023

Emergent interactions due to resource competition in CRISPR-mediated genetic activation circuits

K. Manoj and D. Del Vecchio

IEEE CDC

Accepted

2022

Population-Level Model of the Transient Dynamics of a Toggle Switch with Growth Feedback

D. Hirsh and D. Del Vecchio

IEEE CDC

Accepted

2022

Identifiability of linear noise approximation models of chemical reaction networks from stationary distributions

T. Grunberg and D. Del Vecchio

IEEE CDC

Accepted

2022

Analytical and computational study of the stochastic behavior of a chromatin modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

IEEE CDC

Accepted

2022

Design of a long-term memory genetic toggle switch inspired by chromatin modification circuits

U. Kwan and D. Del Vecchio

IEEE CDC

Accepted

2022

Model reduction and stochastic analysis of the histone modification circuit

S. Bruno, R. Williams, and D. Del Vecchio

European Control Conference

Accepted

March 2022

The impact of retroactivity on information exchange in molecular communications

F. Ratti, M. Magarini, and D. D. Vecchio

NANOCOM: The ACM International Conference on Nanoscale Computing and Communication

2020

The Enhanced Finite State Projection algorithm using conditional moment closure and time-scale separation

U. Kwan, M. Naghnaeian, and D. Del Vecchio

Proc. IEEE Conf. on Decision and Control

Accepted

July 2020

Trade-offs in Robustness to Perturbations of Bacterial Population Controllers

C. McBride and D. Del Vecchio

Proc. of American Control Conference

Accepted

2020

Time-scale separation based design of biomolecular feedback controllers

T. Grunberg and D. Del Vecchio

IEEE CDC, Accepted

2019

Stochastic analysis of genetic feedback controllers to reprogram a pluripotency gene regulatory network

Simone Bruno, M. Ali Al-Radhawi, Eduardo D. Sontag, and Domitilla Del Vecchio

Proc of American Control Conference

Accepted

January 2019

Genetic Circuit-Host Ribosome Transactions: Diffusion-Reaction Model

Carlos Barajas and Domitilla Del Vecchio

Proc of American Control Conference

Accepted

January 2019

Approximation of the Chemical Master Equation using conditional moment closure and time-scale separation

Ukjin Kwon, Mohammad Naghnaeian and Domitilla Del Vecchio

Proc of American Control Conference

Accepted

Reprogramming cooperative monotone dynamical systems

R. Shah and D. Del Vecchio

IEEE Conf. on Decision and Control

Accepted

August 2018

A Model for Resource Competition in CRISPR-Mediated Gene Repression

P. Chen, Y. Qian, and D. Del Vecchio

IEEE Conf. on Decision and Control

Accepted

August 2018

A Singular Singular Perturbation Problem Arising from a Class of Biomolecular Feedback Controllers

Y. Qian and D. Del Vecchio

IEEE Conf. on Decision and Control

Accepted

August 2018

Stochastic multistationarity in a model of the hematopoietic stem cell differentiation network

M. Ali Al-Radhawi, N. S. Kumar, E. D. Sontag, and D. Del Vecchio

IEEE Conf. on Decision and Control

Accepted

August 2018

Resource Sensor Design for Quantifying Resource Competition in Genetic Circuits

C. McBride and D. Del Vecchio

IEEE Conf. on Decision and Control

Accepted

August 2018

Multi-time-scale biomolecular ‘quasi-integral’ controllers for set-point regulation and trajectory tracking

Y. Qian, T. Grunberg, and D. Del Vecchio

Proc. American Control Conf.

To Appear

March 2018

Robust Moment Closure Method for the Chemical Master Equation

M. Naghnaeian and D. Del Vecchio

CCTA

Accepted

2017

Analyzing and Exploiting the Effects of Protease Sharing in Genetic Circuits

C. McBride and D. Del Vecchio

Proc. IFAC World Congress

To Appear

March 2017

Model order reduction for Linear Noise Approximation using time-scale separation

N. Herath and D. Del Vecchio

Proc. of IEEE Conference on Decision and Control,

2016

Mitigation of ribosome competition through distributed sRNA feedback

Y. Qian and D. Del Vecchio

Proc. of IEEE Conference on Decision and Control

2016

Controller design under safety specifications for a class of monotone hybrid automata

d. Hoehener and D. Del Vecchio,

Proc. of IEEE Conference on Decision and Control,

2016

Lane Departure Assist: A Formal Approach

D. Hohener, G. Huang, and D. Del Vecchio

Proc. of IEEE Conference on Decision and Control,

2016

Model reduction for a class of singularly perturbed stochastic differential equations : Fast variable approximation

N. Herath and D. Del Vecchio

Proc. of American Control Conference,

2016

Loading as a Design Parameter of Genetic Circuits

N. Kumar and D. Del Vecchio,

Proc. of American Control Conference

2016

A Dynamical Model for the Low Efficiency of Induced Pluripotent Stem Cell Reprogramming

H. Abdallah, Y. Qian, and D. Del Vecchio,

Proc. of American Control Conference,

2016

An N-stage Cascade of Phosphorylation Cycles as an Insulation Device for Synthetic Biological Circuits

R. Shah and D. Del Vecchio,

Proc. of to European Control Conference,

2016

Semi-autonomous Intersection Collision Avoidance through Job-shop Scheduling

H. Ahn and D. Del Vecchio,

ACM Proc. of Hybrid Systems: Computation and Control,

2016

How retroactivity impacts\ the robustness of genetic networks

S. Mou and D. Del Vecchio

Proc. of IEEE Conference on Decision and Control,

2015

A contraction approach to o\ utput tracking via high gain feedback

A. Hamadeh, E. D. Sontag and D. Del Vecchio

Proc. of IEEE Conference on Decision and Control,

2015

Experimental Testing of a Supervisor for\ Multi-vehicle collision Avoidance at Intersections

H. Ahn, A Rizzi, A. Colombo and D. Del Vecchio,

Proc. of IROS,

2015

Safety Control of a Class of Stochastic Order Preserving Systems with Application to Collision Avoidance near Stop Signs

M. Forghani, J. McNew, D. Hoehener, and D. Del Vecchio

Proc. of American Control Conference,

2015

Stochastic Hybrid Models for Predicting the Behavior of Drivers Facing the Yellow-Light-Dilemma

D. Hoehener, P. A. Green, and D. Del Vecchio,

Proc. of American Control Conference

(Invited Paper)

2015

Model reduction for a class of singularly perturbed stochastic differential equations

N. Herath, A. Hamadeh, and D. Del Vecchio

Proc. of American Control Conference,

2015

Effective interaction graphs arising from resource limitations in gene networks

Y. Qian and D. Del Vecchio

Proc. of American Control Conference,

2015

Mitigation of resource competition in synthetic genetic circuits through feedback regulation

A. Hamadeh and D. Del Vecchio

Proc. IEEE Conf. on Decision and Control

2014

Limitations and Trade-offs in Gene Expression due to Competition for Shared Cellular Resources

A. Gyorgy and D. Del Vecchio.

Proc. IEEE Conf. on Decision and Control,

(Invited Paper)

2014

Integral Action with Time Scale Separation: A Mechanism for Modularity in Biological Systems

P. M. Rivera and D. Del Vecchio

Proc. IEEE Conf. on Decision and Control,

2014

Design of safety distributed control under bounded communication delay

D. Bresh-Pietri and D. Del Vecchio

Proc. American Control Conference,

(Invited Paper)

2014

Supervisory control for intersection collision avoidance in the presence of uncontrolled vehicles

H. Ahn and D. Del Vecchio

Proc. American Control Conference,

2014

Tradeoffs between retroactivity and noise in connected transcriptional components

N. Herath and D. Del Vecchio

Proc. American Control Conference,

2014

Retroactivity Attenuation through Signal Transduction Cascades

P. M. Rivera and D. Del Vecchio.

Proc. American Control Conference

2014

Supervisory Control for Collision Avoidance in Vehicular Networks with Imperfect Measurements

E. Dallal, A. Colombo, D. Del Vecchio, and S. Lafortune

Proc. IEEE Conference on Decision and Control

2013

How slaves affect a master module in gene transcription networks

A. Gyorgy and D. Del Vecchio.

. Proc. IEEE Conference on Decision and Control

(Invited Paper)

2013

Robust multi-agent collision avoidance through scheduling

L. Bruni, A. Colombo, and D. Del Vecchio

Proc. IEEE Conference on Decision and Control

2013

A Control Theory Approach to Engineering Biomolecular Networks

D. Del Vecchio

Proc. IFAC Symposium on Nonlinear Control Systems (NOLCOS)

(Extended version submitted to IFAC Annual Reviews in Control: A Control Theoretic Framework for Modular Analysis and Design of Biomolecular Networks)

2013

Optimal Design of Phosphorylation-Based Insulation Devices

P. M. Rivera and D. Del Vecchio.

Proc. American Control Conference

2013

Supervisory Control for Collision Avoidance in Vehicular Networks Using Discrete Event Abstractions

E. Dallal, A. Colombo, D. Del Vecchio and S. Lafortune.

Proc. American Control Conference,

2013.

Retroactivity to the Input and Thevenin's Theorem for Complex Gene Transcription Networks

A. Gyorgy and D. Del Vecchio.

Proc. IEEE Conf. on Decision and Control

(Invited Paper)

2012

Stochastic Analysis of Retroactivity in Transcriptional Networks through Singular Perturbation

R. Ghaemi and D. Del Vecchio

Proc. American Control Conference

2012.

Efficient algorithms for collision avoidance at intersections

A. Colombo and D. Del Vecchio

. Hybrid Systems: Computation and Control,

2012

Development and experimental validation of a semi-autonomous cooperative active safety system

R. Verma and D. Del Vecchio.

Proc. IEEE Conf. on Decision and Control

( Invited Paper)

2011

Safety control of piece-wise continuous order preserving systems

R. Ghaemi and D. Del Vecchio.

Proc. IEEE Conf. on Decision and Control,

(Invited Paper)

2011

Supervisory control of differentially flat systems based on abstraction

A. Colombo and D. Del Vecchio

Proc. IEEE Conf. on Decision and Control,

2011

Retroactivity Attenuation in Signaling Cascades

H. R. Ossareh and D. Del Vecchio

Proc. IEEE Conf. on Decision and Control

(Invited Paper)

2011

A Contraction Theory Approach to Singularly Perturbed Systems with Application to Retroactivity Attenuation

D. Del Vecchio and J-J. Slotine

Proc. IEEE Conf. on Decision and Control,

2011

Control of Hidden Mode Hybrid Systems: Algorithm Termination

R. Verma and D. Del Vecchio.

Proc. of International IEEE Conference on Intelligent Transportation Systems

( Invited Paper)

2011

Automated Vehicle-to-Vehicle Collision Avoidance at Intersections

M. Hafner, D. Cunningham, L. Caminiti, and D. Del Vecchio

Proc. of World Congress on Intelligent Transport Systems

2011

Tuning an Activator-Repressor Clock Employing Retroactivity

S. Jayanthi, A. Rosenberg, and D. Del Vecchio

Proc. American Control Conference,

(Invited Paper)

2011.

Control of Hybrid Automata with Hidden Modes: Translation to a Perfect State Information Problem .

R. Verma and D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control,

2010

Formal Design of a Provably Safe Robotic Roundabout System.

J. Duperret, M. Hafner, and D. Del Vecchio.

Proc. of IEEE/RSJ International Conference on Intelligent Robots and Systems,

2010

The Impact of Retroactivity on the Input/Output Characteristic of a Signaling Component

A. C. Ventura, P. Jiang, L. Van Wassenhove, A. J. Ninfa, S. D. Merajver, and D. Del Vecchio.

Proc. of Dynamic Systems and Control Conference

(Invited Paper).

2010

Design of an insulation device using phosphotransfer systems

S. Jayanthi and D. Del Vecchio.

Proc. of IEEE International Symposium on Circuits and Systems (ISCAS),

(Invited Paper).

2010.

Computation of Safety Control for Uncertain Piecewise Continuous Systems on a Partial Order.

M. Hafner and D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control,

2009.

Continuous Control of Hybrid Automata with Imperfect Mode Information Assuming Separation between State Estimation and Control.

R. Verma and D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control,

2009.

On the Compromise between Retroactivity Attenuation and Noise Amplification in Gene Regulatory Networks.

S. Jayanthi and D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control

(Invited Paper)

2009

Design of Insulating Devices for In Vitro Synthetic Circuits.

E. Franco, D. Del Vecchio and R. M. Murray.

Proc. of IEEE Conference on Decision and Control,

(Invited Paper)

2009.

Partial Order Techniques for Vehicle Collision Avoidance: Application to an Autonomous Roundabout Test-bed.

V. Desaraju, H. C. Ro, M. Yang, E. Tay, S. Roth, D. Del Vecchio

Proc. of International Conference on Robotics and Automation (ICRA)

2009.

A Separation Principle for a Class of Hybrid Automata on a Partial Order.

D. Del Vecchio, M. Malisoff, and R. Verma

Proc. of American Control Conference

2009.

Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity.

D. Del Vecchio and E. D. Sontag.

Proc. of European Control Conference (ECC),

(Selected for a Special Issue of the European Journal of Control)

2009

Retroactivity Attenuation in Transcriptional Networks: Design and Analysis of an Insulation Device

D. Del Vecchio and S. Jayanthi.

Proc. of IEEE Conference on Decision and Control

(Invited Paper).

December 2008, Cancun

Longitudinal Vehicle Dynamics Scaling and Implementation on a HIL Setup

R. Verma, D. Del Vecchio, and H. Fathy.

Proc. of the Dynamic Systems and Control Conference,

October 2008, Ann Arbor.

A Systems Theory with Retroactivity: Application to Transcriptional Modules

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

Proc. of American Control Conference,

June 2008, Seattle.

A Partial Order Approach for Low Complexity Control of Block Triangular Hybrid Automata

D. Del Vecchio

Proc. of IEEE Conference on Decision and Control,

December 2007, New Orleans.

Observer-based Control for Block-triangular Hybrid Automata.

D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control

,(Invited Paper).

December 2007, New Orleans

Evaluating the Robustness of a Biochemical Network Model

R. Ghaemi and D. Del Vecchio.

Proc. of IEEE Conference on Decision and Control

December 2007, New Orleans.

Design and Analysis of an Activator-Repressor Clock in E. coli

D. Del Vecchio

Proc. of American Control Conference

July 2007, New York.

Dynamics and Control of Synthetic Bio-molecular Networks

D. Del Vecchio and E.D. Sontag

Proc. of American Control Conference,

(Tutorial Paper)

July 2007, New York.

A Partial Order Approach to Discrete Dynamic Feedback in a Class of Hybrid Systems

D. Del Vecchio

Hybrid Systems: Computation and Control,

April 2007, Pisa.

Discrete Dynamic Feedback for a Class of Hybrid Systems on a Lattice

D. Del Vecchio

IEEE CCA/CACSD/ISIC

(Invited Paper)

2006, Munich.

Cascade Discrete-Continuous State Estimators for a Class of Monotone Systems

D. Del Vecchio and R.M. Murray.

Proc. of IFAC

2005, Praha.

Existence of Cascade Discrete-Continuous State Estimators for Systems on a Partial Order

D. Del Vecchio and R.M. Murray.

Hybrid Systems: Computation a nd Control,

2005 Zurich, Switzerland.

Repressilators and Promotilators: Loop Dynamics in Gene Regulatory Networks

H. El Samad, D. Del Vecchio, and M. Khammash.

Proc. of American Control Conference,

(Invited Paper)

2005

Existence of Discrete State Estimators for Hybrid Systems on a Lattice

D. Del Vecchio and R.M. Murray.

Proc. of IEEE Conference on Decision and Control,

(Invited Paper)

2004 Atlantis, Bahamas.

Identification of Decision Rules in a Human Controlled System: Vehicles at a Traffic Intersection

C. L. Walton, D. Del Vecchio, and R. M. Murray.

Proc. of International Conference of Robotics and Automation

2004, New Orleans.

Vision as a Compensatory Mechanism for Disturbance Rejection in Upwind Flight

M. B. Reiser, J. S. Humbert, M. J. Dunlop, D. Del Vecchio, R. M. Murray, M. H. Dickinson.

Proc. of American Control Conference(Winner of best student paper competition)

2004, Boston.

Discrete State Estimators for a Class of Hybrid Systems on a Lattice

D. Del Vecchio and R. M. Murray.

Hybrid Systems: Computation and Control

2004 Philadelphia, Pennsylvania.

Observation of Guarded Command Programs

D. Del Vecchio and E. Klavins.

Proc of IEEE Conference on Decision and Control,

2003 Maui, Hawaii.

Classification of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona.

Proc. of European Control Conference

2003 Cambridge (UK).

Segmentation of Human Motion into Dynamics Based Primitives with Application to Drawing Tasks

D. Del Vecchio, R. M. Murray, and P. Perona

Proc of. American Control Conference

2003 Denver, Colorado.

Primitives for Human Motion: A Dynamical Approach

D. Del Vecchio, R. M. Murray, and P. Perona

Proc. of IFAC

2002 Barcelona, Spain.

An Adaptive Learning Control for Feedback Linearizable Systems.

D. Del Vecchio, R. Marino, and P. Tomei.

Proc. of American Control Conference,

Washington, VA 2001.

Adaptive Learning Control for Robot Manipulators.

D. Del Vecchio, R. Marino, and P. Tomei

Proc. of American Control Conference

Washington, VA 2001.

Selected Abstracts

Multi-modality in gene regulatory networks with slow promoter kinetics

M. Ali, E. D. Sontag, and D. Del Vecchio

q-Bio Conference

August 2017

Understanding and Mitigating the Effects of Limited Transcriptional Resources in Mammalian Cells

Ross Jones, Y. Qian, Ron Weiss, and Domitilla Del Vecchio

SEED Conference

selected for podium presentation

July 2017

Characterizing the effect of shared transcriptional resource in mammalian cells

Ross Jones, Y. Qian, Velia Siciliano, Domitilla Del Vecchio, and Ron Weiss

Mammalian Synthetic Biology Workshop 3.0

selected for podium presentation

May 2016

A semi-autonomous algorithm for multi-vehicle collision avoidance at intersections with multi-conflict points

H. Ahn and D. Del Vecchio

. IROS Conference

2015

The role of ribosome autocatalysis and negative feedback in resource competition

F. Chandra and D. Del Vecchio.

FOSBE

Boston 2015

Resource Limitations Lead to Hidden Interactions in Gene Networks

Y. Qian, H-H. Huang, and D. Del Vecchio.

SEED Conference

Boston, 2015

Isocost lines determine the economy of shared cellular resources.

A. Gyorgy, J. Jimenez, D. Del Vecchio

SEED Conference

Manhattan Beach, CA, 2014

Combating context-dependence in biological circuits with a load driver.

D. Mishra, P. M. Rivera-Ortiz, D. Del Vecchio, and R. Weiss

International Conference on Systems Biology,

Denmark, 2013

Modular Composition of Gene Transcription Networks.

A. Gyorgy and D. Del Vecchio

International Conference on Systems Biology

Denmark, 2013.

Modularity in Complex Gene Transcrition Networks.

A. Gyorgy and D. Del Vecchio

International Conference on Systems Biology,

Toronto, 2012.

Insulation Mechanisms of in vivo Biomolecular Circuits.

K. Nilgiriwala, P. M. Rivera, and D. Del Vecchio.

International Conference on Systems Biology

Toronto, 2012.

Impact of Retroactivity on Transcriptional Components.

S. Jayanthi and D. Del Vecchio

The 5th Annual q-bio Conference on Cellular Information Processing,

Santa Fe, 2012.

Engineering Insulation from Retroactivity of the Frequency Response of Covalent Modification Cycles.

D. Del Vecchio

IEEE Biomedical Circuits & Systems Conference,

San Diego, 2011.

Enforcing Safety of Cyber-Physical Systems Using Flatness and Abstraction.

A. Colombo and D. Del Vecchio.

IEEE/ACM Second International Conference on Cyber-Physical Systems

Chicago, 2011.

A Control Theory Approach to Engineering Biomolecular Circuits.

D. Del Vecchio

33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Boston, 2011.

The Impact of Retroactivity on the Signal Processing of Transduction Networks.

P. Jiang, A. C. Ventura, S. Merajver, E. D. Sontag, A. J. Ninfa, and D. Del Vecchio.

The 5th Annual q-bio Conference on Cellular Information Processing,

Santa Fe, 2011

Retroactivity changes the input/output steady-state characteristic of a transcriptional component.

S. Jayanthi and D. Del Vecchio

SB5.0: The 5th International Meeting on Synthetic Biology

Stanford, 2011

A Dynamics Perspective on Modularity in Biomolecular Networks.

P. Jiang, A. C. Ventura, S. D. Merajver, A. J. Ninfa, and D. Del Vecchio.

International Conference on Systems Biology,

Edinburgh, 2010.

Long Signaling Cascades Attenuate Retroactivity.

H. R. Ossareh, A. C. Ventura, S. D. Merajver, and D. Del Vecchio.

International Conference on Systems Biology

Edinburgh, 2010

Control of Hybrid Automata with Imperfect Mode Information

D. Del Vecchio

Second Workshop on Numerical Software Verification

San Francisco 2009

From Retroactivity to Insulation: a Novel Engineering Principle Learned from Natural Bio-molecular Systems

D. Del Vecchio,

Institute for Biological Engineering Conference

San Francisco 2009

Tutorial Session: Partial order techniques for the analysis and synthesis of hybrid and embedded systems

Organizer: D. Del Vecchio Contributors: Jean-François Raskin (Computer Science Dept., Université Libre de Bruxelles), Georgios E. Fainekos and G Pappas (GRASP Lab, Upenn), Edward A. Lee (EECS, UC Berkeley), Derek Caveney and Lorenzo Caminiti (Toyota Technical Center, Ann Arbor)

Proc. of Conference on Decision and Control,

New Orleans 2007.

Modules and Retroactivity: Theoretical Framework, Analysis, and Design.

D. Del Vecchio, A. J. Ninfa, and E. D. Sontag

International Conference on Systems Biology

Long Beach, 2007.

An Introduction to Control of Synthetic Bio-molecular Systems

D. Del Vecchio

Proc. of Conference on Decision and Control

New Orleans 2007.

Submitted Conference Papers