Frequently Asked Questions

Q: How should I interpret the alignment plots?
A: Pink lines connect identical bases where both bases are exonic in human and mouse. Blue lines connect identical bases in all other cases.

Q: What do the different evolutionary metrics mean? For more detailed explanation, please refer to our paper.

Q: What would a coding gene look like?
A: As you might expect, coding genes align extremely well with high transcript-transcript identy and transcript-genome identity and almost always have every splice site conserved. The indel rate is low, with much less indels at exons than at introns. Here is how coding gene ACTB would look with our alignments and metrics.

The slncky Evolution Browser was developed as a collaboration between the Garber Lab at UMass Medical and the Regev Lab at the Broad Institute.