***********************************2024/2025: LOOKING FOR NEW GRADUATE STUDENTS AND POST-DOCS TO START IN THE FALL ON A NEW EXCITING PROJECT ON ENGINEERING CELLULAR MEMORIES********************************************* Del Vecchio’s group focuses on model-based analysis, design, and control of biomolecular circuits in living cells, both bacterial and mammalian. A core foundational problem we are interested in is context-aware design strategies for genetic circuits, such that desired behavior is conserved across different genetic and cellular contexts. Our main current applications are: multiplexed bio-sensing in bacteria, cell fate reprogramming including control of chromatin state through novel genetic circuits, and design of artificial cell fate differentiation circuits in bacteria and mammalian cells.
Our current ability of designing synthetic genetic circuits bottom up, that is, our ability to create larger systems from the composition of simpler functional units...
The behavior of biomolecular systems in living cells is noisy due to the intrinsic stochasticity of biochemical reactions. Stochasticity leads to subtle tradeoffs in the design of synthetic circuits...
(Post-doc position available for experimental work) The fate of a cell is encoded by a specific signature of transcription factor (TF) levels. Gene regulatory networks (GRNs), in turn, dictate TF levels...
(Archived- no longer active) We have been working since 2006 on (cooperative) active safety systems to prevent collisions with focus on traffic intersections...
N. Nolan, MT Laub, and D. Del Vecchio
Proc. American Control Conference
Accepted
March 2024
Simone Bruno, Felipe A. Campos, Yi Fu, Domitilla Del Vecchio, Ruth J. Williams
SIAM Journal on Applied Dynamical Systems
Accepted
May 2024
H. Du, S. Bruno, K. Overholt, S. Palacios, H.-H. Huang, C. Barajas, B. Gross, C. Lee, H. K. Evile, N. Rufino de Sousa, A. G. Rothfuchs, and D. Del Vecchio
Biosensors and Bioelectronics: X
Accepted
May 2024