Glenn Laboratory for the Science of Aging

As MSNBC reports (I did not read the original article in Lancet yet), experimental vaccine against Alzheimer’s was successfully developed and tried on a number of Alzheimer’s patients, most of which were followed till their death up to 6 years. Vaccine was designed to clear the brain from a-beta plaques. It did just that as post-mortem analysis showed. The problem is … those patients did not get any less dementia nor lived any longer. The most obvious conclusion - plaques do not cause Alzheimer’s or dementia, they are either protective or irrelevant for patho-physiology of the disease.

I am thinking that counting plaques as the measure of Alzheimer’s severity in mice is very misleading at this point, and might get exponentially more complicated to publish.

Hi guys. God Admin is talking. Welcome to the Guarente lab blog!  

Here we are going to discuss lab issues and science of aging.

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